CE-MS for metabolomics: Developments and applications in the period 2008-2010 |
| |
Authors: | Ramautar Rawi Mayboroda Oleg A Somsen Govert W de Jong Gerhardus J |
| |
Institution: | Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands. r.ramautar@lumc.nl |
| |
Abstract: | This review provides an update of the state-of-the-art of CE-MS for metabolomic purposes, covering the scientific literature from July 2008 to June 2010. This review describes the different analytical aspects with respect to non-targeted and targeted metabolomics and the new technological developments used in CE-MS for metabolomics. The applicability of CE-MS in metabolomics research is illustrated by examples of the analysis of biomedical and clinical samples, and for bacterial and plant extracts. The relevant papers on CE-MS for metabolomics are comprehensively summarized in a table, including, e.g. information on sample type and pretreatment, and MS detection mode. Future considerations such as challenges for large-scale and (quantitative) clinical metabolomics studies and the use of sheathless interfacing and different ionization techniques are discussed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|