Comparative isoconversional thermal analysis of Artemisia vulgaris hydrogel and its acetates; a potential matrix for sustained drug delivery |
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| Authors: | Muhammad Farid-ul-Haq Muhammad Amin Muhammad Sher Taskin Aman Khan Fahmeeda Kausar |
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| Institution: | 1. Institute of Chemistry, University of Sargodha, Sargodha, Pakistan  https://orcid.org/0000-0001-5193-6317;2. Department of Chemistry, The University of Lahore, Sargodha, Pakistan https://orcid.org/0000-0002-0222-3991;3. Institute of Chemistry, University of Sargodha, Sargodha, Pakistan https://orcid.org/0000-0001-9216-2338;4. Institute of Chemistry, University of Sargodha, Sargodha, Pakistan https://orcid.org/0000-0002-8778-5984;5. School of Chemistry and Chemical Engineering (SCCE), Shanghai Jiao Tong University (SJTU), Shanghai, China https://orcid.org/0000-0002-4632-7725 |
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| Abstract: | Abstract Artemisia vulgaris hydrogel (AVH) was acetylated (AAVH) and characterized by FTIR, CP/MAS 13C-NMR spectroscopic techniques and thermogravimetric analysis. Flynn–Waal–Ozawa model was used to investigate thermal degradation kinetics. Energy of activation (Ea) values of first and major thermal degradation steps were found to be 128.14 and 116.85 kJmol?1 for AVH and AAVH, respectively. Thermodynamic triplet, order of degradation reaction, integral procedural decomposition temperature (IPDT) and comprehensive index of intrinsic thermal stability (ITS) were also taken into account. In vitro caffeine release from AVH-based matrix tablets indicates potential of AVH for the development of oral delivery systems for sustained drug release. |
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| Keywords: | Artemisia vulgaris hydrogel isoconversional thermal analysis acetylation drug release solid-state NMR |
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https://orcid.org/0000-0001-5193-6317;2. Department of Chemistry, The University of Lahore, Sargodha, Pakistan