Cellulose esters in drug delivery |
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Authors: | Kevin J Edgar |
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Institution: | (1) Eastman Chemical Company, 1972, Kingsport, TN 37662, USA |
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Abstract: | Cellulose esters have played a vital role in the development of modern drug delivery technology. They possess properties that
are not only well-suited to the needs of pharmaceutical applications, but that enable construction of drug delivery systems
that address critical patient needs. These properties include very low toxicity, endogenous and/or dietary decomposition products,
stability, high water permeability, high T
g, film strength, compatibility with a wide range of actives, and ability to form micro- and nanoparticles. This suite of properties
has enabled the creation of a wide range of drug delivery systems employing cellulose esters as key ingredients. The following
is a review of the most important types of these systems, and of the critical roles played by cellulose esters in making them
work, focusing on more recent developments. |
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Keywords: | Amorphous matrix Cellulose acetate Cellulose acetate butyrate Cellulose acetate phthalate Cellulose acetate propionate Cellulose ester Controlled release Drug delivery Enteric coating Matrix release Osmotic pump Zero-order release |
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