Methods for the determination of neutral drugs as well as betablockers and β2-sympathomimetics in aqueous matrices using GC/MS and LC/MS/MS |
| |
Authors: | T A Ternes Roman Hirsch Jutta Mueller and Klaus Haberer |
| |
Institution: | (1) ESWE-Insitute for Water Research and Water Technology, Soehnleinstrasse 158, D-65201 Wiesbaden, Germany e-mail: ternes@goofy.zdv.Uni-Mainz.de, DE |
| |
Abstract: | An analytical method has been developed which allows the determination of 22 different neutral and weakly basic drugs belonging
to several different medicinal classes like antiphlogistics, betablockers, β2-sympathomimetics, lipid regulators, antiepileptic agents, psychiatric drugs and vasodilators in waste water as well as in
river and drinking water. A method including solid phase extraction, derivatization by silylation and detection by GC/MS permits
detection down to 5 ng/L. The recovery rates mostly exceeded 70%. However, the determination of phenazone, carbamazepine,
cyclophosphamide, ifosfamide and pentoxiphylline is frequently disturbed by organic co-extractants in real samples of rivers
and waste waters. Therefore, a time saving alternative method has been developed, combining solid phase extraction (as an
enrichment step) together with detection by LC-electrospray/MS/MS allowing the measurement of 5 neutral drugs. Detection limits
down to 10 ng/L have been achieved even for organically highly contaminated waters like sewage treatment plant effluents.
Received: 18 November 1997 / Revised: 18 March 1998 / Accepted: 21 March 1998 |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|