| 新型N-甲基吲哚类衍生物的设计、合成及抗肿瘤活性研究 |
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| 引用本文： | 陈剑锋,金花,王迪,潘雨婷,陈李鹏,尉松瑶,付中华,夏艳.新型N-甲基吲哚类衍生物的设计、合成及抗肿瘤活性研究[J].分子科学学报,2020(2):125-130,I0003. |
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| 作者姓名： | 陈剑锋 金花 王迪 潘雨婷 陈李鹏 尉松瑶 付中华 夏艳 |
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| 作者单位： | 长春工业大学化学与生命科学学院;延边大学附属医院中心实验室 |
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| 基金项目： | 国家自然科学基金资助项目(21502008);延边大学校内项目(延大科字(2018)37号). |
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| 摘 要： | 本文以吲哚骨架为起点,设计合成了5个含吲哚骨架的新型有机小分子(4a-4e),通过NMR,IR和MS对目标化合物进行了结构表征.采用MTS法测试了目标化合物对SMMC-7721,Hela,MCF-7和HepG2癌细胞的体外抗肿瘤活性.结果表明,部分化合物选择性地作用于一种细胞,显示出较强的抑制肿瘤细胞增殖的活性,值得进一步研究.
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| 关 键 词： | 吲哚 费歇尔合成 抗肿瘤活性 MTS |
Design,synthesis and antitumor activity of novel N-methylindole derivatives |
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| CHEN Jian-feng,JIN Hua,WANG Di,PAN Yu-ting,CHEN Li-peng,WEI Song-yao,FU Zhong-hua,XIA Yan.Design,synthesis and antitumor activity of novel N-methylindole derivatives[J].Journal of Molecular Science,2020(2):125-130,I0003. |
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| Authors: | CHEN Jian-feng JIN Hua WANG Di PAN Yu-ting CHEN Li-peng WEI Song-yao FU Zhong-hua XIA Yan |
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| Institution: | (College of Chemistry and Life Science,Changchun University of Technology,Changchun 130012,China;Central Laboratory of Affiliated Hospital,Yanbian University,Yanji 133000,China) |
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| Abstract: | In this paper, five novel small organic molecules(4 a-4 e) containing indole skeleton were designed and synthesized from the indole skeleton. The target compounds were characterized by NMR, IR and MS. Using p-methylphenylhydrazine hydrochloride as a raw material. The in vitro antitumor activity of the target compound against SMMC-7721, Hela, MCF-7 and HepG2 cancer cells was tested by MTS assay. The in vitro activity results indicated that some of the compounds selectively act on a kind of cell line and showed strong activity in inhibiting tumor cell proliferation, which deserves further study. |
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| Keywords: | indole Fischer synthesis antitumor activity MTS |
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