| H_8[P_2Mo_(17)Co(OH_2)O_(61)]和H_8[P_2Mo_(17)Ni(OH_2)O_(61)]的抑酶活性研究 |
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| 引用本文： | 谢乐芳,李莉莉,陈丙年,王力.H_8[P_2Mo_(17)Co(OH_2)O_(61)]和H_8[P_2Mo_(17)Ni(OH_2)O_(61)]的抑酶活性研究[J].分子科学学报,2017,33(5). |
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| 作者姓名： | 谢乐芳 李莉莉 陈丙年 王力 |
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| 作者单位： | 1. 集美大学食品与生物工程学院,福建厦门,361021;2. 厦门大学附属中山医院演武分院,福建厦门,361005 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 合成了2种过渡金属取代的多酸H_8P_2Mo_(17)Co(OH_2)O_(61)]和H_8P_2Mo_(17)Ni(OH_2)O_(61)],并对其抑酶活性进行了研究.结果表明,这2种化合物对酪氨酸酶均有有效的抑制效果.抑制机理表明2种化合物均是可逆竞争型抑制剂.H_8P_2Mo_(17)Co(OH_2)O_(61)]和H_8P_2Mo_(17)Ni(OH_2)O_(61)]的半抑制率IC_(50)值分别为(0.434 0±0.000 4)和(0.466 5±0.012 0)mmol/L,抑制常数K_Ⅰ分别为0.216 7和0.220 4mmol/L.该研究能够扩大多金属氧酸盐的应用范围.
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| 关 键 词： | 多酸 酪氨酸酶 抑制机理 |
Research of the inhibition activities of H8[P2Mo17Co(OH2)O61]and H8[P2Mo17Ni(OH2)O61] on enzyme |
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| XIE Le-fang,LI Li-li,CHEN Bing-nian,WANG Li.Research of the inhibition activities of H8[P2Mo17Co(OH2)O61]and H8[P2Mo17Ni(OH2)O61] on enzyme[J].Journal of Molecular Science,2017,33(5). |
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| Authors: | XIE Le-fang LI Li-li CHEN Bing-nian WANG Li |
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| Abstract: | In this paper,two kinds of transition metal ions substituted phosphomolybdic acids H8P2Mo17Co(OH2)O61],H8P2Mo17Ni(OH2)O61] were synthesized and their inhibition activity on tyrosinase were studied.The results show that the two compounds have potent inhibitory activities on mushroom tyrosinase.Inhibition mechanism shows that the two compounds are reversible and competitive inhibitors.The IC50 values of H8 P2Mo17Co(OH2)O61] and H8 P2Mo17Ni(OH2)O61] were (0.434 0±0.000 4),(0.466 5±0.012 0) mmol/L,respectively.The inhibition constants K1 were 0.216 7,0.220 4 mmol/L,respectively.This research can expand the application range of the polyoxometalates. |
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| Keywords: | phosphomolybdic acid trosinase inhibition mechanism |
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