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| 高压芒刺静电场对小鼠LFA-1和ICAM-1表达的影响 | |
| 引用本文： | 孙迎春,刘晓冬,杨秀兰,张翔宇,史唤之,王锡录.高压芒刺静电场对小鼠LFA-1和ICAM-1表达的影响[J].分子科学学报,2005,21(5):46-50. |
| 作者姓名： | 孙迎春 刘晓冬 杨秀兰 张翔宇 史唤之 王锡录 |
| 作者单位： | 1. 东北师范大学物理学院,吉林,长春,130024 2. 吉林大学公共卫生学院卫生部重点放射生物实验室,吉林,长春,130021 3. 吉林农业大学信息技术学院,吉林,长春,130118 |
| 基金项目： | 吉林省科技发展计划;教育部留学回国人员科研启动基金 |
| 摘 要： | 采用不同电压高压芒刺静电场对小鼠进行全身辐射,荧光免疫流式细胞术检测蛋白表达量的变化.通过时程/量效研究不同电压高压芒刺静电场对细胞表面分子LFA-1和ICAM-1的影响.剂量效应结果表明,LFA-1和ICAM-1在10～20 kV之间处理组的表达量明显高于对照组（P＜0.01）;在30 kV以上电压表达量明显降低（P＜0.05）;时间进程研究结果表明,处理后2 h开始实验组表达量与对照组相比差异显著,一直持续到24 h.不同电压高压芒刺静电场可引起ICAM-1和LFA-1不同的生物效应,二者的相互作用在免疫调节反应中发挥重要功能. |
| 关 键 词： | 高压芒刺静电场 免疫调节 |
| 文章编号： | 1000-9035(2005)05-0046-05 |
| 收稿时间： | 03 7 2004 12:00AM |
| 修稿时间： | 2004年3月7日 |
Effects of high voltage prick electrostatic fields on the expressions of LFA-1 and ICAM-1 |
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| SUN Ying-chun,LIU Xiao-dong,YANG Xiu-lan,ZHANG Xiang-yu,SHI Huan-zhi,WANG Xi-lu.Effects of high voltage prick electrostatic fields on the expressions of LFA-1 and ICAM-1[J].Journal of Molecular Science,2005,21(5):46-50. | |
| Authors: | SUN Ying-chun LIU Xiao-dong YANG Xiu-lan ZHANG Xiang-yu SHI Huan-zhi WANG Xi-lu |
| Institution: | 1.School of Physics, Northeast Normal University, Changchun 130024, China; 2. MH Radiobiology Research Unit, Jilin University,Changchun 130021, China; 3. Jilin University of Agriculture, Communication Technology College, Changchun 130118, China |
| Abstract: | Whole bodies of mice was radiated by high voltage prick electrostatic fields.Immunofluorescent after different doses of high voltage prick electrostatic fields by timecourse and doseeffect studies. The doseeffect studies showed that ICAM1 and LFA1 expressions 10~20 kV groups increased significantly(P<0.01),while that of 30 kV and above groups decreased significantly(P<0.05);Timecourse results showed that ICAM1 and LFA1 expressions of experimental groups singnificantly differed from control group beginning from 2 h to more than 24 h.The different doses of high voltage prick electrostatic fields might cause different changes of ICAM1 on peritoneal macrophages and LFA1 on thymocytes,which suggested that high voltage prick electrostatic fields had potential immuneregulatory effects and the changes of ICAM1 and LFA1might play important roles in immune modulation. |
| Keywords: | ICAM-1 LFA-1 |
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