| 相溶解度法研究不同环糊精对丹皮酚的增溶作用 |
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| 引用本文： | 张冕,王德堂,万芳.相溶解度法研究不同环糊精对丹皮酚的增溶作用[J].分子科学学报,2012(5):422-426. |
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| 作者姓名： | 张冕 王德堂 万芳 |
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| 作者单位： | 荆楚理工学院化工与药学院;荆楚理工学院医学院 |
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| 基金项目： | 湖北省高等学校优秀中青年科技创新团队计划支持项目(T200911);荆楚理工学院校级课题资助项目(ZR201110) |
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| 摘 要： | 采用相溶解度法,通过测定丹皮酚在不同温度不同浓度的β-环糊精(β-CD)、羟丙基-β-环糊精(HP-β-CD)、羟乙基-β-环糊精(HE-β-CD)、取代度为4的磺丁基醚-β-环糊精(SBE4-β-CD)以及取代度为7的磺丁基醚-β-环糊精(SBE7-β-CD)中的溶解度,绘制相溶解度曲线,丹皮酚的溶解度均随5种环糊精浓度的增加而成线性增加,相溶解度曲线为AL型,说明丹皮酚与环糊精以1∶1包合,实验结果表明,5种环糊精对丹皮酚均有增溶作用且SBE7-β-CD的增溶效果最佳.
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| 关 键 词： | 丹皮酚 环糊精 相溶解度法 |
Enhanced solubility of paeonolum with different types of cyclodextrins by phase solubility method |
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| ZHANG Mian,WANG De-tang,WAN Fang.Enhanced solubility of paeonolum with different types of cyclodextrins by phase solubility method[J].Journal of Molecular Science,2012(5):422-426. |
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| Authors: | ZHANG Mian WANG De-tang WAN Fang |
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| Institution: | 1 (1.College of Chemical Engineering and Pharmacy,Jingchu University of Technology,Jingmen 448000,China; 2.Medical College,Jingchu University of Technology,Jingmen 448000,China) |
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| Abstract: | The phase solubility curves of paeonolum(PAE) were obtained by determining the solubility of paeonolum in different concent rations of β-CD and it’s derivatives(HP-β-CD、HE-β-CD、SBE4-β-CD and SBE7-β-CD at different temperatures.The experimental results indicated that the phase solubility curves of paeonolum in five different cyclodextrins were AL styles and the inclusion ratio of paeonolum versus cyclodextrins was 1∶1.PAE solubility in the water can be improved by introducing CD derivatives into the system.The best enhancing effect of paeonolum solubility was SBE7-β-CD. |
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| Keywords: | paeonolum cyclodextrin phase solubility |
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