Facile synthesis of spiroisoquinolines based on photocycloaddition of isoquinoline-1,3,4-trione with oxazoles |
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| Authors: | Huang Chengmei Yu Haitao Miao Zhengrui Zhou Jie Wang Shuai Fun Hoong-Kun Xu Jianhua Zhang Yan |
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| Institution: | School of Chemistry and Chemical Engineering, Key Laboratory of Analytical Chemistry for Life Science, Ministry of Education of China, Nanjing University, Nanjing, P R China. njuzy@nju.edu.cn. |
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| Abstract: | Photocycloaddition of isoquinoline-1,3,4-trione and 5-methoxyoxazoles affords spiroisoquinolineoxetanes with high regio- and diastereoselectivity. The spiroisoquinolineoxetanes can be conveniently converted into novel spiroisoquinolineoxazoline derivatives through acid catalyzed sequential reactions. |
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