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Synthesis of sedamine by tethered cyclofunctionalisation
Authors:Bates Roderick W  Boonsombat Jutatip
Institution:Department of Chemistry, University of Exeter, Stocker Road, Exeter EX4 4QD, UK. R.W.Bates@exeter.ac.uk
Abstract:The piperidine alkaloid, (+)-sedamine has been synthesised starting from (S)-1-phenyl-3-butenol using a stereoselective, intramolecular palladium-catalysed cyclocarbonylation reaction of a substituted hydroxylamine.
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