A methionine-based turn-on chemical sensor for selectively monitoring Hg2+ ions in 100% aqueous solution |
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Authors: | Yang Mi-Hwa Lohani Chuda Raj Cho Hyeongjin Lee Keun-Hyeung |
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Institution: | Bioorganic Chemistry Lab, Department of Chemistry, Inha University, 253-Yunghyun-dong, Nam-gu, Incheon 402-751, South Korea. |
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Abstract: | Dansyl-labeled methionine is synthesized by solid-phase synthesis, and found to be a highly sensitive and selective sensor for Hg(2+). The sensor sensitively detects Hg(2+) ions in aqueous solution by a turn-on response; however, the sensor detects Hg(2+) ions by a turn-off response in organic and mixed aqueous-organic solutions. We investigated the binding stoichiometry, binding constant, and binding mode of the sensor under various solvent conditions. In 100% aqueous solution, 2 : 1 complexation of the sensor with Hg(2+) ions is more favorable than 1 : 1 complexation, whereas the sensor preferentially forms a 1 : 1 complex in 100% CH(3)CN or in 50% CH(3)CN-aqueous solutions. Results reveal that the stoichiometry of the sensor-Hg(2+) complex plays an important role in the type of response to Hg(2+) ions, and that 2 : 1 complexation is required for a turn-on response to Hg(2+) ions in aqueous solution. |
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