Gold Nanorod–Photosensitizer Complex Obtained by Layer‐by‐Layer Method for Photodynamic/Photothermal Therapy In Vitro |
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| Authors: | Seung Beom Kim Tae Heon Lee Prof Il Yoon Prof Young Key Shim Prof Woo Kyoung Lee |
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| Institution: | Photodynamic Therapy Institute and School of Nano System Engineering, Inje University, 197?Injero, Gimhae, Gyeongnam 621‐749 (Republic of Korea) |
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| Abstract: | Gold nanorod (GNR)–photosensitizer (PS) complex was prepared using anionic PS (sodium salt of purpurin‐18) and cationic poly(allylamine hydrochloride) by layer‐by‐layer method, and was characterized by transmission electron microscopy, UV‐vis spectroscopy, and zeta potential. The GNR–PS complex is a promising agent for synergistic (photothermal and photodynamic) therapy (PTT/PDT), in which PTT generates heat as well as operates the PS release which maximize the following PDT activity. The combined dual therapy, PTT followed by PDT, exhibits a significantly higher photocytotoxicity result based on synergistic effect of hyperthermia from PTT as well as singlet oxygen photogeneration from PDT. |
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| Keywords: | drug delivery drug release gold nanorods photodynamic therapy photothermal therapy synergistic therapy |
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