|
|||||
|
|
Asymmetric Catalytic Aziridination of Cyclic Enones |
|
| Authors: | Francesco De Vincentiis Giorgio Bencivenni Dr Fabio Pesciaioli Andrea Mazzanti Dr Giuseppe Bartoli Prof Patrizia Galzerano Dr Paolo Melchiorre Prof Dr |
| Institution: | 1. Dipartimento di Chimica Organica “A. Mangini”, Università di Bologna, Viale Risorgimento 4, 40136 Bologna (Italy);2. ICIQ—Institute of Chemical Research of Catalonia, Av. Pa?sos Catalans 16, 43007 Tarragona (Spain), Fax: (+34)?977‐920‐823;3. ICREA—Institució Catalana de Recerca i Estudis Avan?ats, Pg. Lluís Companys 23, 08010 Barcelona (Spain) |
| Abstract: | The first catalytic method for the asymmetric aziridination of cyclic enones is described. The presented organocatalytic strategy is based on the use of an easily available organocatalyst that is able to convert a wide range of cyclic enones into the desired aziridines with very high enantiomeric purity and good chemical yield. Such a method may very well open up new opportunities to stereoselectively prepare complex chiral molecules that possess an indane moiety, a framework that is found in a large number of bioactive and pharmaceutically important molecules |
| Keywords: | asymmetric catalysis aziridines domino reactions enones organocatalysis |