Anticancer Potencies of PtII‐ and PdII‐linked M2L4 Coordination Capsules with Improved Selectivity |
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| Authors: | Dr Anife Ahmedova Dr Denitsa Momekova Masahiro Yamashina Dr Pavletta Shestakova Prof?Dr Georgi Momekov Prof?Dr Munetaka Akita Dr Michito Yoshizawa |
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| Institution: | 1. (+359)?2‐962‐5438;2. Faculty of Chemistry and Pharmacy, Sofia University, 1, Sofia, Bulgaria;3. Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria;4. Chemical Resources Laboratory, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan;5. NMR Laboratory, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria;6. (+81)?45‐924‐5230 |
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| Abstract: | PtII‐ and PdII‐linked M2L4 coordination capsules, providing a confined cavity encircled by polyaromatic frameworks, exhibit anticancer activities superior to cisplatin against two types of leukemic cells (HL‐60 and SKW‐3) and pronounced toxicity against cisplatin‐resistant cells (HL‐60/CDDP). Notably, the cytotoxic selectivities of the PtII and PdII capsules toward cancerous cells are up to 5.3‐fold higher than that of cisplatin, as estimated through the non‐malignant/malignant‐cells toxicity ratio employing normal kidney cells (HEK‐293). In addition, the anticancer activity of the coordination capsules can be easily altered upon encapsulation of organic guest molecules. |
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| Keywords: | anticancer activity cancer cisplatin coordination capsules encapsulation platinum ion |
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