Nanoscale Metal–Organic Framework–Hemoglobin Conjugates |
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| Authors: | Dr Weiqi Wang Dr Lei Wang Prof Yubin Huang Prof Zhigang Xie Prof Xiabin Jing |
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| Institution: | 1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, P. R. China;2. The University of Chinese Academy of Sciences, Beijing, P. R. China |
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| Abstract: | A metal–organic framework (MOF)–protein conjugate, NH2‐MIL‐125(Ti)‐hemoglobin MIL‐125(Ti)‐Hb], was synthesized by a covalent postmodification strategy. The crystalline structure was maintained after chemical and protein modification. The content of grafted Hb was tuned by the stoichiometric ratio and reached 50 wt % if the mass ratio of MIL‐125(Ti)/Hb was 1:1.25 in the feed. The oxygen‐transporting capacity of grafted Hb was kept, and the P50 (the half O2 pressure saturated with O2) and Hill coefficients of the MIL‐125(Ti)‐Hb conjugate were found to be 22.9 mm Hg and 2.35, respectively, which are close to the respective values of free Hb. All the results indicate that the MIL‐125(Ti)‐Hb conjugate could be potentially used as an oxygen carrier. |
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| Keywords: | conjugate materials hemoglobin metal– organic frameworks nanoparticles oxygen carriers |
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