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HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery |
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| Authors: | Hoyeon Lee Soojin Uhm Jung‐Won Shin Hyun Mi Jeon Sun Dongbang Hyo Sung Jung Yun‐Cheol Na Prof Chulhun Kang Prof Jong Seung Kim |
| Institution: | 1. The School of East-West Medical Science, Kyung Hee University, Yongin, Korea;2. Department of Chemistry, Korea University, Seoul, Korea;3. Omics System Research Team, Korea Basic Science Institute, Seoul, Republic of Korea |
| Abstract: | A galactose‐appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. |
| Keywords: | anticancer drugs camptothecin cancer drug delivery galactose |