Synthesis of a Near‐Infrared BODIPY Dye for Bioimaging and Photothermal Therapy |
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| Authors: | Yang Liu Nan Song Prof Li Chen Dr Shi Liu Prof Zhigang Xie |
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| Institution: | 1. Department of Chemistry, Northeast Normal University, Changchun, P.?R. China;2. State key of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, P.?R. China |
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| Abstract: | The development of robust photothermal agents for near‐infrared (NIR) imaging is a great challenge. Herein, we report the design and synthesis of a new photothermal agent, based on the aza‐boron‐dipyrromethene framework (azaBDP). This compound possessed excellent photostability and high photothermal‐conversion efficiency (50 %) under NIR laser irradiation. When the photothermal properties of this compound were utilized for tumor inhibition, stable long‐term fluorescence was observed in living animals. Photothermal treatment efficiently suppressed tumor growth, as evidenced by in vitro and in vivo experiments. Furthermore, NIR emission could be detected by using an imaging system and therapeutic self‐monitoring was achieved by using NIR imaging. |
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| Keywords: | aza-BODIPY dyes fluorescence heterocycles imaging agents photothermal therapy |
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