An Unconventional Polymerization Route to Hydrophilic Fluorescent Organic Nanoparticles for Multicolor Cellular Bioimaging |
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| Authors: | Qingfu Ban Yinglai Hou Dr Wen Sun Dr Jianxin Chen Xiaofei Zhang Dr Si Wu Prof Jie Kong |
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| Institution: | 1. Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, China;2. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China;3. Max Planck Institute for Polymer Research, Mainz, Germany;4. CAS Key Laboratory of Soft Matter Chemistry, Key Laboratory of Optoelectronic Science and Technology, Innovation Centre of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China |
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| Abstract: | We demonstrated an unconventional polymerization route to synthesize hydrophilic fluorescent organic nanoparticles (FONs) for multicolor cellular bioimaging in this contribution. The route benefits from our unexpected discovery of a rapid polymerization reaction between 1,6‐hexanediol dipropiolate and 2,4,6‐triazide‐1,3,5‐triazine under the catalysis of N,N,N′,N′′,N′′‐pentamethyldiethylenetriamine (PMDETA). Interestingly, the 2,4,6‐triazide‐1,3,5‐triazine and PMDETA system can also induce rapid free radical polymerization at room temperature. The as‐prepared FONs exhibited promising water solubility and stability with an average diameter of 20 nm. The excitation wavelength‐dependent fluorescent properties endow the FONs with blue, yellow, and red fluorescent emission under UV, blue, and green excitation, respectively. The cytotoxicity of FONs was investigated by using a Cell Counting Kit (CCK‐8) assay, which indicated good biocompatiblity. More importantly, the cell uptake experiment verified the FONs were excellent fluorescent nanoprobes for multicolor cellular bioimaging. Therefore, this unconventional route provides a novel fabrication strategy of highly hydrophilic FONs for biomedical applications. |
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| Keywords: | biocompatibility fluorescent organic nanoparticles hydrophilicity multicolor cellular bioimaging |
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