黄芪口服液中8种重金属元素含量的测定

在2015年版《中国药典》的基础上,采用原子荧光光谱法和电感耦合等离子体质谱法对黄芪口服液中的铅、砷、镉、汞、铜、锌、镍和铬进行测定,并对所用试剂、器皿,赶酸时间,内标的种类和加入方式进行了优化。结果表明,在样品处理前对器皿采用硝酸(30%)处理,赶酸时间在1.5h以上,以手动方式加入单内标103 Rh溶液,可以得到较准确、稳定的测定结果,8种元素测定的相对标准偏差(RSD)均小于4%,Hg、As、Cu、Pb、Zn、Cd、Ni、Cr的检出限分别为0.089、0.21、0.45、0.15、0.45、0.025、0.35和0.39μg/L,8种元素的加标回收率在92.0%～114%。方法对于黄芪口服液中痕量元素的检测,结果稳定,过程简单,引入污染小。

Determination of 8 heavy metals in astragalus oral liquid

In this paper, on the basis of the 2015 edition of Chinese pharmacopoeia, using atomic fluorescence spectrometry and inductively coupled plasma mass spectrometry for astragalus oral liquid in the lead, arsenic, cadmium, mercury, copper, zinc,nickel and chromium were determined, and the used reagents, vessel, cast time, within the target species and join method were optimized.Results show that before the sample processing for vessels with 30% nitric acid treatment, the acid time when more than 1.5 h, to join single internal standard manually,you can get more accurate and stable determination results, RSD are less than 4% for the determination of 8 kinds of element, Hg, As, Cu, Pb, Zn, Cd, Ni and Cr of detection limit were 0.089 u g/L, 0.21 u g/L, 0.45 u g/L, 0.15u g/L, 0.45 u g/L, 0.025 u g/L, 0.35 u g/L and 0.39 u g/L,The recoveries of 8 elements were between 92% and 114%.This method can detect trace elements with stable results, simple process and less possibility of introducing blank.