| 金属组学在肝癌诊断及治疗中的应用 |
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| 引用本文： | 张艳丽,#,毕鹏伟,江鑫垚,王永安,蒋婷婷,王欣,李超.金属组学在肝癌诊断及治疗中的应用[J].中国无机分析化学,2024,14(1):56-62. |
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| 作者姓名： | 张艳丽 # 毕鹏伟 江鑫垚 王永安 蒋婷婷 王欣 李超 |
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| 作者单位： | 1. 安徽医科大学第二附属医院肿瘤科;2. 安徽医科大学基础医学院化学教研室;3. 安徽医科大学第二临床学院;4. 安徽医科大学第一临床学院 |
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| 基金项目： | 安徽省自然科学基金(No.2108085MA26)、安徽省转化医学研究所研究基金(No.2022zhyx-C77)、安徽医科大学临床医学专业“早期接触科研”训练计划项目(2022-ZQKY-162)、安徽省级临床重点专科建设项目(项目编号:卫科教秘[2018]180号)#共同第一 |
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| 摘 要： | 金属组学与医学的交叉结合为疾病的诊断及治疗提供了新的研究方向。以肝癌为例，首先介绍了金属组学在肝癌诊断中的应用，包括常用的检测设备和诊断方法；最后介绍了金属组学在肝癌治疗中的应用，除了传统的铂类药物，还发展了钒复合物、钌复合物及砷类药物。金属组学除了用于肝癌的诊断和治疗，也可以预测疗效，如血清Zn与Fe含量的上升，Cu含量下降，提示预后较好。随着新技术的不断发展，金属组学将会在肝癌的诊断及治疗中发挥更大的价值。
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| 关 键 词： | 肝癌 金属组学 诊断 治疗 |
| 收稿时间： | 2023/9/18 0:00:00 |
| 修稿时间： | 2023/10/6 0:00:00 |
The application of metallomics in diagnosis and treatment of liver cancer |
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| Zhang Yanli,#,Bi Pengwei,Jiang Xinyao,Wang Yongan,Jiang Tingting,Wang Xin and Li Chao.The application of metallomics in diagnosis and treatment of liver cancer[J].Chinese Journal of Inorganic Analytical Chemistry,2024,14(1):56-62. |
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| Authors: | Zhang Yanli # Bi Pengwei Jiang Xinyao Wang Yongan Jiang Tingting Wang Xin and Li Chao |
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| Institution: | The Second Affiliated Hospital,Anhui Medical University,Hefei,School of Basic Medical Sciences,Anhui Medical University,Hefei,The Second Clinical Medical College,Anhui Medical University,Hefei,The First Clinical Medical College,Anhui Medical University,Hefei,School of Basic Medical Sciences,Anhui Medical University,Hefei,The Second Clinical Medical College, Anhui Medical University, Hefei, Anhui 230000, China,School of Basic Medical Sciences,Anhui Medical University,Hefei,The Second Affiliated Hospital,Anhui Medical University,Hefei;China;School of Basic Medical Sciences,Anhui Medical University,Hefei;China;The Second Clinical Medical College,Anhui Medical University,Hefei;China;The First Clinical Medical College,Anhui Medical University,Hefei;China |
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| Abstract: | The intercrossing of metallomics and medicine provides a new research direction for the diagnosis and treatment of diseases. In this review, the commonly used methods of metallomics in liver cancer research were introduced. Then the value of targeted and non-targeted metallomics methods in diagnosis were summarized, and finally the application of metallomics in liver cancer treatment was introduced. With the continuous development of metallomics, it will play a more important role in the diagnosis and treatment of liver cancer. |
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| Keywords: | metallomics liver cancer diagnosis treatment |
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