微波消解-ICP-MS法测定药用明胶空心胶囊中微量重金属元素

采用微波消解技术,建立了一种电感耦合等离子体质谱法测定明胶空心胶囊中Cr,Co,Ni,Cu,Zn,As,Cd,Hg和Pb 9种微量重金属元素的方法。确定了微波消解仪和等离子体质谱仪的最佳操作参数,研究共存离子的干扰和消除方法,选择了各元素的测定同位素,以Ge,Rh和Tl为内标补偿基体效应,建立了样品测定方法。应用拟定的方法测定了不同生产厂家、不同批次的空心胶囊中微量重金属的含量。方法对试样中各元素测定的相对标准偏差为1.5%~14.1%,加标回收率在90.0%~102.0%。结果表明,方法简便、快速、灵敏,满足于空心胶囊中9种重金属元素的测定要求。

Determination of Trace Heavy Metal Elements in Vacant Gelatin Capsules by ICP-MS after Microwave-Asisted Digestion

A method for determination of 9 trace heavy metal elements in vacant gelatin capsules by inductively coupled plasma mass spectrometry (ICP-MS) after microware-assisted digested digestion .The experiments optimized parameters of microwave digestion and ICP-MS. The interference from coexistent ions on determination of the 9 elements and the interference eliminating methods were studied. 72 Ge, 103Rh and 205Tl were chosen as internal standards to compensate for matrix effects. Contents of 9 trace heavy metal elements in vacant capsules come from different factories and different batches were determined by proposed method. The relative standard deviations (RSD) are in the range of 1.52 %-14.13% , and the recoveries of standard addition are in the range of 90.0%-102.0%. The results indicate that the proposed method is simplicity, speediness and sensitivity, and is suitable for determination contents of the 9 trace heavy metal elements in vacant capsules.