Synthesis of 2-amino-3,6-di(het)arylpyridines from 5-cyano-3,6-di(het)aryl-1,2,4-triazines and arylhydrazines via the SNipso/aza-Diels–Alder reaction sequence |
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Institution: | 1. Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russian Federation;2. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russian Federation |
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Abstract: | Reaction between 5-cyano-3,6-di(het)aryl-1,2,4-triazines and arylhydrazines with the following aza-Diels–Alder autoclave reaction affords hardly available 2-amino-3,6-di(het)aryl-pyridines in up to 67% yield after two steps and in 75% yield for the one-pot way. The compounds obtained can be promising for medicinal chemistry. |
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Keywords: | 2-aminopyridines 6-amino-2 2’-bipyridines 1 2 4-triazines arylhydrazines autoclave processes |
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