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A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins |
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| Institution: | 1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. National University of Science and Technology ‘MISIS”, 119049 Moscow, Russian Federation |
| Abstract: | 3-Aryl-5-methylidene-2-thiohydantoins were constructed in one-pot reaction of aryl isothiocyanates and 3-morpholino- alanine in alkaline medium with the subsequent treatment with boiling hydrochloric acid. |
| Keywords: | 2-thiohydantoins exocyclic C=C bond heterocyclization isothiocyanates amino acids |
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