Effect of hyaluronic acid encapsulation in a silica hydrogel matrix on drug penetration through the skin |
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| Institution: | 1. D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation;2. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russian Federation;1. Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, 230026 Hefei, China;2. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;1. Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, Russian Federation;2. Siberian State Medical University, 634050 Tomsk, Russian Federation;3. National Research Tomsk Polytechnic University, 634050 Tomsk, Russian Federation;4. Scientific Center for Mental Health, 115522 Moscow, Russian Federation;5. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 634028 Tomsk, Russian Federation;1. Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León C.P. 66455, Mexico;2. Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada;3. Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Nuevo León 64890, Mexico;1. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;2. Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation;3. National Research Center ‘Kurchatov Institute’, 123182 Moscow, Russian Federation;4. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation |
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| Abstract: | It has been found that the encapsulation of high molecular weight hyaluronic acid in a biologically relevant silica hydrogel matrix provides its accelerated penetration into the skin compared to free acid. The developed hybrid hydrogels, in which high molecular weight hyaluronic acid retains its pronounced anti-inflammatory properties and strong hydrating effect, can become the basis for new, more effective soft formlations for the treatment of inflammatory skin diseases, as well as for products used in the beauty industry. It has been shown that the penetration of hyaluronic acid from the hybrid hydrogels depends on the conditions of their synthesis, the average molecular weight and the loading of the acid. |
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| Keywords: | silica hyaluronic acid hybrid hydrogel skin penetration rate apparent permeability coefficient |
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