Capability of DNA-fueled molecular machine in tuning association rate of DNA-functionalized gold nanoparticles |
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| Authors: | Ting-jie Song Hao-jun Liang |
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| Institution: | 11319. CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, 230026, China
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| Abstract: | The capability of our newly developed DNA-machine-driven strategy in tuning the association rate of DNAAuNPs was compared with that of linker-addition strategy which has potential practical applications in different fields. The new established strategy shows its superiority to the linker-addition strategy in tuning the association rate of DNA-AuNPs in both pre-incubation treatment and non-incubation treatment conditions since its two components (a complex and a catalystoligonucleotide) can be individually optimized to make the machine run at an optimal rate. This strategy will provide a more convenient and flexible option in designing an oligonucleotide detection system and building a complex and versatile device. |
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