pH-responsive Micelles from a Blend of PEG-<Emphasis Type="Italic">b</Emphasis>-PLA and PLA-<Emphasis Type="Italic">b</Emphasis>-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation |
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| Authors: | Yan-Ling Xu Ao-Ting Qu Ru-Jiang Ma Ang Li Zhen-Kun Zhang Zhi-Qiang Shang Yao-Fang Zhang Lu-Xia Bu Ying-Li An |
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| Institution: | 1.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry,Nankai University,Tianjin,China;2.College of Basic Science, Chemistry Experiment Teaching Center,Tianjin Agricultural University,Tianjin,China |
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| Abstract: | pH-responsive micelles with a biodegradable PLA core and a mixed PEG/PDPA shell were prepared by self-assembly of poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA) and poly(2-(diisopropylamino)ethyl methacrylate)-b-poly(lactic acid) (PDPA-b-PLA). The micellization status with different pH and the enzyme degradation behavior were characterized by 1H-NMR spectroscopy, dynamic light scattering measurement and zeta potential test. The pH turning point of PDPA block was determined to be in the range of 5.5?7.0. While the pH was above 7.0, the PDPA block collapsed onto the PLA core and could protect the PLA core from invasion of enzyme, as a result, the micelle exhibited a resistance to the enzymatic degradation. |
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