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Doxorubicin-loaded PLGA microparticles with internal pores for long-acting release in pulmonary tumor inhalation treatment |
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| Authors: | Tian-shi Feng Hua-yu Tian Cai-na Xu Lin Lin Michael Hon-Wah Lam Hao-jun Liang Xue-si Chen |
| Institution: | 1. CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering,University of Science and Technology of China, Hefei 230026, China;Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences,Changchun 130022, China;Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China;Advanced Laboratory of Environmental Research and Technology(ALERT), Joint Advanced Research Center,USTC-City U, Suzhou 215124, China;2. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences,Changchun 130022, China;3. Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China;Advanced Laboratory of Environmental Research and Technology(ALERT), Joint Advanced Research Center,USTC-City U, Suzhou 215124, China;4. CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering,University of Science and Technology of China, Hefei 230026, China;Advanced Laboratory of Environmental Research and Technology(ALERT), Joint Advanced Research Center,USTC-City U, Suzhou 215124, China |
| Abstract: | Doxorubicin(DOX) loaded poly(lactic-co-glycolic acid)(PLGA) microparticles with internal pores(MP-D) were developed for long-acting release in pulmonary inhalation treatment. The PLGA microparticles exhibited favorable aerodynamic properties for pulmonary delivery. In vitro drug release profile suggested that MP-D have the advantage of long-term maintenance of drug concentrations. MTT assay demonstrated the in vitro anti-tumor efficiency of the DOX loaded PLGA microparticles. Furthermore, melanoma lung metastasis model was established to determine the in vivo antitumor efficiency. The mice treated with MP-D showed significantly fewer lesions than the untreated ones. The survival analysis indicated that MP-D prolonged the survival time of tumor-bearing mice. These results suggested that DOX loaded PLGA microparticles with internal pores have the potential to be used as long-acting release carriers in clinical lung cancer treatment. |
| Keywords: | Doxorubicin Poly(lactic-co-glycolic acid) Internal pores Long-acting release Pulmonary inhalation |
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