| IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER |
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| 作者姓名： | 计剑 封麟先 邱永兴 俞小洁 杨士林 |
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| 作者单位： | Department of Polymer Science and Engineering，Zhejiang University，Hangzhou，310027，Department of Polymer Science and Engineering，Zhejiang University，Hangzhou，310027，Department of Polymer Science and Engineering，Zhejiang University，Hangzhou，310027，Department of Polymer Science and Engineering，Zhejiang University，Hangzhou，310027，Department of Polymer Science and Engineering，Zhejiang University，Hangzhou，310027 |
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| 基金项目： | Supported by the National Natural Science Foundation of China and Huoyindong Education Foundation |
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| 摘 要： | A new reactive graft copolymer, poly(tetramthylene glycol) - graft-w-propyl sodiumsulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH_2CH_2CH_2SO_3~-Na~+), was synthesizedby the cationic polymerization of a-w-bifunctional PEG macromonomer (O?CH_2—PEG——CH_2 CH_2 CH_2 SO_3 Na) and THF. The obtained copolymer exhibits the expected structureas indicated by the result of characterization. Two amino acids (L-arginine, L-tyrosine)were covalently attached to the copolymer after converting the sulfonate group to sulfonylchloride. So the new reactive graft copolymer (PTMG-g-PEG-CH_2CH_2CH_2SO_3~-Na~+) isexpected to be very useful in attachment of potentially bioactive moieties to polymer viaa hydrophilic PEG spacer.
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| 收稿时间： | 1996-04-12 |
IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER* |
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| JI Jian,FENG Linxian,QIU Yongxin,YU Xiaojie,YANG Shilin.IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER[J].Chinese Journal of Polymer Science,1997,0(2):180-186. |
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| Authors: | JI Jian FENG Linxian QIU Yongxin YU Xiaojie YANG Shilin |
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| Institution: | Department of Polymer Science and Engineering; Zhejiang University; Hangzhou; 310027 |
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| Abstract: | A new reactive graft copolymer, poly(tetramthylene glycol) - graft-w-propyl sodiumsulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH2CH2CH2SO3-Na+), was synthesizedby the cationic polymerization of a-w-bifunctional PEG macromonomer (O?CH2—PEG——CH2 CH2 CH2 SO3 Na) and THF. The obtained copolymer exhibits the expected structureas indicated by the result of characterization. Two amino acids (L-arginine, L-tyrosine)were covalently attached to the copolymer after converting the sulfonate group to sulfonyl chloride.So the new reactive graft copolymer(PTMG-g-PEG-CH2CH2SO3-Na+) is expected to be very useful in attachment of potentially bioactive moieties to polymer via a hydrophilic PEG spacer. |
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| Keywords: | Potentially bioactive moieties Polyether Biocompatible materials |
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