Nanocrystals for large Stokes shift-based optosensing |
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| Institution: | 1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;2. Analytical & Testing Center, Sichuan University, Chengdu 610064, China;3. College of Light Industry and Textile and Food Engineering, Sichuan University, Chengdu 610065, China;1. College of Medicine and Health Sciences, Khalifa University, PO Box 127788, Abu Dhabi, United Arab Emirates;2. Department of Chemistry, Khalifa University of Science and Technology, Main Campus, P.O. Box 127788, Abu Dhabi, United Arab Emirates;3. Institut de Chimie de Nice, UMR 7272, CNRS, Université Côte d′Azur ? Parc Valrose, 06108 Nice cedex 2, France;4. Department of Immunology and Physiology, College of Medicine and Health Sciences, Khalifa University, PO Box 127788, Abu Dhabi, United Arab Emirates;5. Biomedical Engineering, Healthcare Engineering Innovation Center, Khalifa University, PO Box 127788, Abu Dhabi, United Arab Emirates;6. Center for Biotechnology, Khalifa University, PO Box 127788, Abu Dhabi, United Arab Emirates;7. KU Research and Data Intelligence Support Center (RDISC) AW 8474000331, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab Emirates;1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;2. State Key Laboratory of Virology and Center for Analytical Microbiology, Wuhan Institute of Virology, Chinese Academy of Sciences, China |
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| Abstract: | Stokes shift is an important feature of fluorescence, which reveals the energy loss between the excitation and the emission. For most fluorescent materials(e.g., organic dyes and proteins), the large overlap between the absorption and emission spectra endow them a small Stokes shift that induced reabsorption by fluorophore itself. Although the self-absorption can be effectively reduced due to the emergence of fluorescent nanomaterials, fluorescence attenuation is still observed in aggregated or concentrated nanocrystals, causing reduced sensitivity of biosensors. Therefore, increasing the Stokes shift can effectively improve the performance of nano-agents based biosensing. In this critical review, through understanding the Stokes shift from the viewpoint of self-absorption, the influence of Stokes shift on fluorescence properties are discussed. Based on the principle of changing the Stokes shift of fluorescent nanomaterials, we described the methods for constructing various optically large Stokes shift-based nanomaterials, and the application of these nanocrystals in biosensing is especially concerned in this review. |
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| Keywords: | Stokes shift Self-absorption Band gap Optical nanocrystals Biosensing |
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