MOFs and bone: Application of MOFs in bone tissue engineering and bone diseases |
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| Institution: | 1. Department of Chemistry, Jinan University, Guangzhou 510632, China;2. Department of Orthopedics, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China;1. Hospital of Stomatology, Jilin University, Changchun 130021, China;2. School of Materials Science and Engineering, Hainan University, Haikou 570228, China;3. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China;4. School of Stomatology, China Medical University, Shenyang 110001, China;5. Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China;1. Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China;2. Maanshan High-Tech Research Institute of Nanjing University, Maanshan 238200, China;3. The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China;1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;2. Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University, Hangzhou 310000, China;3. Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China;1. Hengyang Medical School, University of South China, Hengyang 421001, China;2. School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China;1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry; School of Future Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, China;2. Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China;3. Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200438, China |
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| Abstract: | Metal-organic frameworks (MOFs), a class of hybrid materials, consist of organic linkers and bridging metal ions or clusters. Their tunable pore sizes, large surface area, good biocompatibility, structural variability in combination with materials and chemicals, and osteogenic effects provide potential approaches for bone tissue engineering and bone diseases. And there are more and more research on MOFs in the field of osteogenesis in recent years. This review presents an overall summary of the application in the bone tissue engineering and bone diseases of MOFs and their composites, starting with the synthesis of MOFs, which discusses the advantages and disadvantages of different syntheses. Then, the biological functions of MOFs are discussed, which are the basics of MOFs applied in the organism. Importantly, mechanisms and abundant applications of MOFs are detailed in the bone tissue engineering and bone diseases. Finally, some prospects of MOFs are discussed, for instance, exploring whether MOFs can be used to treat other bone diseases. |
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