Current development of bicyclic peptides |
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| Institution: | 1. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;2. School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, United Kingdom;1. Key Laboratory for Environmental Pollution Prediction and Control, Gansu Province, College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, China;2. Key Laboratory of Pollutant Chemistry and Environmental Treatment, College of Chemistry and Environmental Science, Yili Normal University, Yining 835000, China;1. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China;2. Pingshan translational medicine center, Shenzhen Bay Laboratory, Shenzhen 518118, China;1. Intelligent Fiber Sensing Technology of Chongqing Municipal Engineering Research Center of Institutions of Higher Education, Chongqing Key Laboratory of Modern Photoelectric Detection Technology and Instrument, Chongqing Key Laboratory of Fiber Optic Sensor and Photodetector, Chongqing University of Technology, Chongqing 400054, China;2. Biodesign Swette Center for Environmental Biotechnology, Arizona State University, Tempe, AZ 85271-5701, United States;3. College of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, China;4. Key Laboratory of Low-grade Energy Utilization Technologies and Systems (Chongqing University), Ministry of Education, Chongqing 400030, China;1. College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong 643000, China;2. College of Chemistry, Sichuan University, Chengdu 610065, China |
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| Abstract: | Bicyclic peptides, a class of polypeptides with two loops within their structure, have emerged as powerful tools in the development of new peptide drugs. They have the potential to bind to challenged drug targets, with antibody-like affinity and selectivity. Meanwhile, bicyclic peptides possess small molecule-like access to chemical synthesis, which is conducive to large-scale synthesis and screening. In the last five years, bicyclic peptide technology has been increasingly developed, and researchers have carried out a variety of studies to elucidate the potential functions of bicyclic peptides. With the continuous development of synthetic methods and the advances of new technology to build bicyclic peptide libraries, bicyclic peptides are now becoming widely used in the development of new drugs for various diseases. This perspective provides an overview of the structure types, synthesis and applications of bicyclic peptides in current drug development, and our own views on future challenges of bicyclic peptides. |
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