| Site-specifically Hydrolytic Cleavage of Oxidized Insulin B Chain With Cu(II) Ion |
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| 作者姓名： | Xue Mei LUO Wei Jiang HE Yu ZHANG Zi Jian GUO Long Gen ZHU* State Key Laboratory of Coordination Chemistry Nanjing University Nanjing |
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| 作者单位： | Xue Mei LUO，Wei Jiang HE，Yu ZHANG，Zi Jian GUO，Long Gen ZHU* State Key Laboratory of Coordination Chemistry，Nanjing University，Nanjing 210093 |
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| 基金项目： | the National Natural Science Foundation of China (Grant Nos. 29871017 and 29823001). |
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| 摘 要： | Selectively chemical cleavage of peptides and proteins is one of the most important reactions in both chemical and biochemical processes. Over the past decade, the interaction of palladium(II) complexes with methionine, cysteine and histidine-containing peptides and proteins and the hydrolytic cleavage of the corresponding amide bond by Pd(II) complexes have been extensively studied1-13. However, reports concerning the directly selective hydrolysis of peptides and proteins with other simple …
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Site-specifically Hydrolytic Cleavage of Oxidized Insulin B Chain With Cu(II) Ion |
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| Xue Mei LUO,Wei Jiang HE,Yu ZHANG,Zi Jian GUO,Long Gen ZHU* State Key Laboratory of Coordination Chemistry,Nanjing University,Nanjing .Site-specifically Hydrolytic Cleavage of Oxidized Insulin B Chain With Cu(II) Ion[J].Chinese Chemical Letters,2000,11(11). |
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| Authors: | Xue Mei LUO Wei Jiang HE Yu ZHANG Zi Jian GUO Long Gen ZHU |
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| Abstract: | Electrospray mass spectrometry investigation shows that denatured oxidized insulin B chain can be selectively cleaved by simple Cu(II) ion and the site of cleavage is at Gly8 - Ser9 bond which is second amide bond left from His 10 in the sequence of oxidized insulin B chain. |
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| Keywords: | Oxidized insulin B chain hydrolytic cleavage electrospray mass spectrometry Cu2+ |
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