| Synthesis of Amphiphilic Hepatocyte Targeting Cholesterylated Thiogalactosides |
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| 作者姓名： | Li HAI Xun SUN Zhi Rong ZHANG Yu LUO Yong WU |
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| 作者单位： | [1]West China School of Pharmacy, Sichuan University, Chengdu 610041 |
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| 摘 要： | Six amphiphilic cholesterylated thiogalactosides la-f with high affinity for the asialoglycoprotein receptor have been synthesized by coupling 2,3,4,6-tetra -O-acetyl-l-thio-β-D-galactopyranose 8 with prepared cholesterol derivatives 7a-f, then by deacetylating. Preliminary results show liposomes containing those galactosides derivatives exhibited higher affinity and transfection activity in hepatoma cells HepG2 and SMMC-7721.
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| 关 键 词： | 两性分子 肝细胞 硫葡糖苷酶 合成方法 天然化合物 |
| 收稿时间： | 2004-09-06 |
Synthesis of Amphiphilic Hepatocyte Targeting Cholesterylated Thiogalactosides |
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| Li HAI Xun SUN Zhi Rong ZHANG Yu LUO Yong WU.Synthesis of Amphiphilic Hepatocyte Targeting Cholesterylated Thiogalactosides[J].Chinese Chemical Letters,2005,16(8):1021-1023. |
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| Authors: | Li;HAI;Xun;SUN;Zhi;Rong;ZHANG;Yu;LUO;Yong;WU |
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| Abstract: | |
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| Keywords: | Hepatocyte target cholesterylated thiogalactosides synthesis |
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