| Synthesis and characterization of a novel amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer |
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| 作者姓名： | Qiu Hua Wu Fang Liang Tian Zhu Wei Xi Ming Song Shu Yao Wu Guo Lin Zhang |
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| 作者单位： | a Key Laboratory of Green Synthesis and Preparative Chemistry of Advanced Materials(Liaoning University), The Education Department of Liaoning Province, Shenyang 110036, China;b College of Chemistry, Liaoning University, Shenyang 110036, China |
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| 基金项目： | 辽宁省教育厅自然科学基金 |
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| 摘 要： | β-Cyclodextrin/poly(γ-benzyl L-glutamate) (β-CD-PBLG) copolymers were synthesized by ring-opening polymerization of N-carboxy-γ-benzyl L-glutamate anhydride (BLG-NCA) in N,N-dimethylformamide (DMF) initiated by mono-amino-β-cyclodex-trin(H2N-β-CD). The structures of the copolymers were confirmed by IR, 1H NMR and GPC. The fluorescence technique was used to determine the critical micelle concentrations (CMC) of copolymer miceU solution, the diameter and the distribution of micelles were characterized by DLS. The results showed that BLG-NCA could be initiated by H2N-β-CD to produce copolymer. The nano-micells were formed by these copolymers in water.
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| 关 键 词： | β-Cyclodextrin Poly(-γ-benzyl-L-glutamate) |
| 收稿时间： | 29 August 2008 |
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