| Interaction between Bifunctional Dioxo Macrocyclic Polyamine Co(II) Complex and DNA in Metallomicellar System |
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| 作者姓名： | Qing Xiang XIANG Hong ZHOU* Xin Yan WANG Xiao Qi YU* Jing Ku BAO Ru Gang XIE |
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| 作者单位： | Qing Xiang XIANG1，Hong ZHOU2*，Xin Yan WANG2，Xiao Qi YU1*，Jing Ku BAO2，Ru Gang XIE 1Department of Chemistry，Sichuan University，Chengdu 610064 2College of Life Science，Sichuan University，Chengdu 610064 |
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| 基金项目： | We are thankful to the National Natural Science Foundation of China for financial support (No. 29872027). |
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| 摘 要： | Artificial enzymes are non-protein molecules that are more simple than natural enzymes, but they also possess high efficiency and specificity. In recent years, the study of enzyme models is one of the most active fields1-2, especially chemical nuclease. Micelles, dynamic colloidal aggregates formed by amphipathic surfactant molecules, can mimic the hydrophobic structure of active site of enzymes because they offer a hydrophobic microenviornment which is similar to the important part located …
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Interaction between Bifunctional Dioxo Macrocyclic Polyamine Co(II) Complex and DNA in Metallomicellar System |
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| Qing Xiang XIANG,Hong ZHOU*,Xin Yan WANG,Xiao Qi YU*,Jing Ku BAO,Ru Gang XIE .Interaction between Bifunctional Dioxo Macrocyclic Polyamine Co(II) Complex and DNA in Metallomicellar System[J].Chinese Chemical Letters,2002,13(3). |
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| Authors: | Qing Xiang XIANG HONG Zhou Xin Yan WANG Xiao Qi YU Jing Ku BAO Ru Gang XIE |
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| Abstract: | The cleavage of DNA (pUC18) by lipophilic macrocyclic polyamine Co(II) complex was investigated in metallomicellar system. The results showed that the conversion of plasmid DNA (pUC18) increases with the increase of the concentration of complex under physiological conditions. |
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| Keywords: | Bifunctional dioxo macrocyclic polyamine complex micellar system cleavage of DNA |
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