An efficient synthesis of 2-(guaiazulen-1-yl)furan derivatives via intramolecular Wittig reactions |
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| Authors: | Dao-Lin Wanga Zhe Donga Jiao Xub Di Lia a College of Chemistry and Chemical Engineering Liaoning |
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| Institution: | Key Laboratory of Synthesis and Application of Functional Compound,Bohai University,Jinzhou 121003,China b Cosmetology Department,Jiamusi Institute,Heilongjiang University of Chinese Medicine,Jiamusi 154007,China |
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| Abstract: | An efficient and mild synthesis of 2-(guaiazulen-1-yl)furans, starting from easily accessible 1-(3-aryl-2-cyanopropenoyl)guaiazulenes, tributylphosphine and acyl chlorides, is described. The strategy employs the intramolecular Wittig protocol as a key step to append the crucial furan ring, leading to the highly functional furans in good yields. |
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| Keywords: | Guaiazulene Furan Intramolecular Wittig reaction |
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