| Photo-responsive nanoparticles for β-lapachone delivery in vitro |
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| 作者姓名： | Huibo Li Changmai Chen Qin An Guoyan Huo Mingtao Run |
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| 作者单位： | a School of Chemistry and Environmental Science, Hebei University, Baoding 071002, China;
b State Key Laboratory of Natural & Biomimetic drugs, The School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
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| 摘 要： | We reported a one-step encapsulation of indocyanine green (ICG) in ZIF-8 nanoparticles (NPs). The as-prepared ICG@ZIF-8 NPs possess an absorption band in the near infrared region and have the good photothermal conversion efficiency.
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| 关 键 词： | Photoresponsive Nanoparticle &beta -Lapachone UV irradiation Treatment of cancer |
| 收稿时间： | 30 August 2017 |
Photo-responsive nanoparticles for β-lapachone delivery in vitro |
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| Huibo Li,Changmai Chen,Qin An,Guoyan Huo,Mingtao Run.Photo-responsive nanoparticles for β-lapachone delivery in vitro[J].Chinese Chemical Letters,2018,29(9):1347-1349. |
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| Authors: | Huibo Li Changmai Chen Qin An Guoyan Huo Mingtao Run |
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| Institution: | a School of Chemistry and Environmental Science, Hebei University, Baoding 071002, China;
b State Key Laboratory of Natural & Biomimetic drugs, The School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
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| Abstract: | Drug efficiency delivery and release to target site play an important role in the treatment of cancer. To achieve these goals, developing drug delivery systems is the key step. The common materials used for drug delivery like liposomes, micelles, dendrimers cannot control the delivery and releasing by spatial and temporal. In this paper, we design a photoresponsive drug delivery system to reduce the side effects of traditional chemotherapy on normal cells and improve therapeutic efficacy in treating cancers. We synthesized two kinds of photo-responsive polymers using two different monomers containing two photoresponsive groups. The two monomers were crosslinked by poly (ethylene glycol) dimethacrylate to form polymers and then encapsulated β-lapachone into the nanoparticles, after UV irradiation, the particle will degrade and release the drug. This method may provide new strategies for the photoresponsive nanomaterials. |
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| Keywords: | Photoresponsive Nanoparticle UV irradiation Treatment of cancer |
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