| Synthesis of 1-Bromo-3-methoxy-4-propoxy-5-iodobenzene——A Novel Efficient Process for the Synthesis of Brominated Aromatic Compound |
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| 引用本文： | Hong Xin SHI *,Hui LIN ,Gérard MANDVILLE Zhejiang Key Lab. of Green-chemical Synthetic Technology,Zhejiang University of Technology,Hangzhou .Department of Chemistry,Institute of Science,Zhejiang University,Hangzhou Université de Paris-Sud,ICMO, Orsay Cédex,France.Synthesis of 1-Bromo-3-methoxy-4-propoxy-5-iodobenzene——A Novel Efficient Process for the Synthesis of Brominated Aromatic Compound[J].中国化学快报,2004,15(3):288-291. |
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| 作者姓名： | Hong Xin SHI * Hui LIN Gérard MANDVILLE Zhejiang Key Lab. of Green-chemical Synthetic Technology Zhejiang University of Technology Hangzhou . |
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| 作者单位： | Hong Xin SHI 1*，Hui LIN 2，Gérard MANDVILLE 3 1Zhejiang Key Lab. of Green-chemical Synthetic Technology，Zhejiang University of Technology，Hangzhou 310014 2.Department of Chemistry，Institute of Science，Zhejiang University，Hangzhou 310012 3Université de Paris-Sud，ICMO，91405 Orsay Cédex，France |
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| 摘 要： | The reaction of aromatic carboxylic acid with oxalyl chloride gives rise to the corresponding acid chloride which without purification is treated with the sodium salt of mercaptopyridine oxide in the presence of 2,2-azo-bisisobutyronitrile (AIBN), radical initiator to give a brominated aromatic compound. After etherification and oxidation, 5-iodovaniline was converted to trisubstituted benzene carboxylic acid which give 1-bromo-3-methoxy-4-propoxy-5-iodobenzene by this new brominating process with a yield of 74%.
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| 关 键 词： | 1-溴-3-甲氧基-4-丙氧基-5-碘代苯 合成 基团取代 溴化作用 |
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