| Multisubstituted pyrazole synthesis via[3+2]cycloaddition/rearrangement/N-H insertion cascade reaction of α-diazoesters and ynones |
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| 作者姓名： | Peng Zhao Zi Zeng Xiaoming Feng Xiaohua Liu |
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| 作者单位： | Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China |
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| 基金项目： | This work is supported by the National Natural Science Foundation of China (Nos. 21625205 and U19A2014). |
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| 摘 要： | The cascade reactions of alkyl α-diazoesters and ynones using Al(OTf)3 as the catalyst are described.A series of 4-substituted pyrazoles were obtained via 3+2] cycloaddition,1,5-ester shift,1,3-H shift,and N-H insertion process.Deuterium labelling experiments,kinetic studies and control experiments were carried out for the rationalization of the mechanism.
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| 关 键 词： | PYRAZOLE Cascade reaction α-Diazoester Ynone Al(OTf)3 |
| 收稿时间： | 17 September 2020 |
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