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Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes |
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| Authors: | Li Jun Yan Quan Zhong Liu Xue Lian Wang Laboratory of Applied Chemistry Pollution Control Technology College of Chemistry Chemical Engineering China West Normal University Nanchong China |
| Institution: | Laboratory of Applied Chemistry and Pollution Control Technology, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China |
| Abstract: | Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities (up to 97% ee). |
| Keywords: | Michael addition Thiottrea Enantioselectivities Nitroalkene and malonate |
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