| Facile synthesis of 9-（N-amino-4-fluoromethyl-3-pyrrolidinyl）-2- fluoro-6-aminopurine from trans-4-hydroxy-L-proline |
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| 作者姓名： | Ye Qing Li Ming Lu Chun Xu Lu Sai Jian Zhu Qi Fa Liu |
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| 作者单位： | Ye Qing Li Ming Lu Chun Xu Lu Sai Jian Zhu Qi Fa Liu Chemical Engineering College，Nanjing University of Science and Technology，Nanjing 210094，PR China |
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| 摘 要： | A novel and simple procedure for synthesis of azanucleoside by Mitsunobu reaction between N-(p-nitrobenzyloxycarbonyl)- trans-4-hydroxy-D-proline methyl ester obtained from trans-4-hydroxy-L-proline after six-step reaction and 2-fluoro-6-azidopurine is described,and azanucleoside is fluorinated by new fluridizer 2,2-difluoro-1,3-dimethylimidazolidine (DFI).All reactions could be carded out under mild condition.
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| 关 键 词： | 超-4-羟基-D-脯氨酸 2-氟乙酰胺-6-重氮乙烷 氟化物氨基 DFI |
| 收稿时间： | 29 April 2007 |
| 修稿时间： | 2007-04-29 |
Facile synthesis of 9-(N-amino-4-fluoromethyl-3-pyrrolidinyl)-2-fluoro-6-aminopurine from trans-4-hydroxy-L-proline |
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| Ye Qing Li Ming Lu Chun Xu Lu Sai Jian Zhu Qi Fa Liu.Facile synthesis of 9-(N-amino-4-fluoromethyl-3-pyrrolidinyl)-2-fluoro-6-aminopurine from trans-4-hydroxy-L-proline[J].Chinese Chemical Letters,2007,18(11):1313-1315. |
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| Authors: | Ye Qing Li Ming Lu Chun Xu Lu Sai Jian Zhu Qi Fa Liu |
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| Institution: | Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094, PR China |
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| Abstract: | A novel and simple procedure for synthesis of azanucleoside by Mitsunobu reaction between N-(p-nitrobenzyloxycarbonyl)- trans-4-hydroxy-D-proline methyl ester obtained from trans-4-hydroxy-L-proline after six-step reaction and 2-fluoro-6-azidopurine is described,and azanucleoside is fluorinated by new fluridizer 2,2-difluoro-1,3-dimethylimidazolidine (DFI).All reactions could be carded out under mild condition. |
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| Keywords: | trans-4-Hydroxy-o-proline 2-Fluoro-6-azidopurine Fluoride azanucleosides Mitsunobu reaction DFI |
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