| Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits |
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| 作者姓名： | Guo Qiang HU Sheng LI Wen Long HUANG |
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| 作者单位： | Guo Qiang HU1*，Sheng LI1，Wen Long HUANG2 1Institute of Pharmacy，Henan Unversity，Kaifeng 475001 2 China Pharmaceutical University，Nanjing 210009 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 4-Amino-3-substituted-5-mercapto-s-triazole derivatives are an important intermediate for the synthesis of biologically active heterocycles 1-4 including antibacterial, antifungal, anticancer agents. Before, the researches mainly focused on its fused hete…
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| 关 键 词： | 嘧啶 三唑 氧杂二唑 肟醚 席夫碱 抗菌活性 |
| 收稿时间： | 2006-01-11 |
Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits |
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| Guo Qiang HU Sheng LI Wen Long HUANG.Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits[J].Chinese Chemical Letters,2006,17(7):899-902. |
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| Authors: | Guo Qiang HU Sheng LI Wen Long HUANG |
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| Abstract: | 4-Amino-5-pyridin-4-yl-s-triazole-3-thiol (1) was sequentally reacted with 3-chloro-1-phenylpropan-1-one to afford 3-(4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl)-1-phenylpropan-1-one (2) followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-13,4oxadiazole-2-chloromethanes to the corresponding oxime (3) and oxime-ethers (4a-e),respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds (5a-e). The antibacterial activity in vitro against Gram-postive (G ) and Gram negative (G-) bacteria was primarily evaluated. |
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| Keywords: | Pyridine triazole oxadiazole oxime-ether schiff base antibacterial activity |
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