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A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood
作者姓名:Jun Liu  ;Jiao Wu  ;You Xing Zhao  ;Yuan Yuan Deng  ;Wen Li Mei  ;Hao Fu Dai
作者单位:a Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
基金项目:国家重点基础研究发展计划(973计划),Science and Technology Foundation of Chinese Academy of Agricultural Sciences
摘    要:A new compound 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl)-5,6,7,8-tetralaydro-4H-chromen-4-one (1) was isolated from the Chinese eaglewood Aquilaria sinensis (Lour.) Gilg]. Its structure was elucidated on the basis of spectral data. Compound I showed cytotoxicity against human gastric cancer cell line (SGC-7901) in vitro by MTT method with the IC50 value of 14.6 μg/mL.

关 键 词:中药  沉香  色酮  细胞毒性

A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood
Jun Liu,;Jiao Wu,;You Xing Zhao,;Yuan Yuan Deng,;Wen Li Mei,;Hao Fu Dai.A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood[J].Chinese Chemical Letters,2008,19(8):934-936.
Authors:Jun Liu  Jiao Wu  You Xing Zhao  Yuan Yuan Deng  Wen Li Mei  Hao Fu Dai
Institution:a Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
Abstract:A new compound 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl)-5,6,7,8-tetrahydro-4H-chromen-4-one (1) was isolated from the Chinese eaglewood Aquilaria sinensis (Lour.) Gilg]. Its structure was elucidated on the basis of spectral data. Compound 1 showed cytotoxicity against human gastric cancer cell line (SGC-7901) in vitro by MTT method with the IC50 value of 14.6 μg/mL.
Keywords:Chinese eaglewood  Aquilaria sinensis  Chromone  Cytotoxicity
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