| Lipase immobilized on HOOC-MCF： A highly enantioselective catalyst for transesterification resolution of （R,S）-1-phenylethanol |
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| 作者姓名： | Ping Xue Xiang Hui Yan Zheng Wang |
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| 作者单位： | Ping Xue~* Xiang Hui Yan Zheng Wang Key Laboratory of Energy Resources and Chemical Engineering，Ningxia University，Yinchuan 750021，China |
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| 摘 要： | Pseudomonas cepacia lipase (PSL) immobilized on the carboxyl-functionalized meso-cellular foams (HOOC-MCF) was used for the transesterification resolution of (R,S)-1-phenylethanol in organic solvent.The results showed that the ee value of (S)-1- phenylethanol and (R)-1-phenylethyl acetate reached 99% with 50% conversion of 1-phenylethanol using toluene as solvent. Furthermore,it was found that PSL/HOOC-MCF exhibited high enantioselectivity in organic solvent with log P≤2 such as toluene and hexane.
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| 关 键 词： | 固化脂肪酶 对映选择性 手性拆分 1-苯基乙醇 |
| 收稿时间： | 19 March 2007 |
| 修稿时间： | 2007-03-19 |
Lipase immobilized on HOOC-MCF: A highly enantioselective catalyst for transesterification resolution of (R,S)-1-phenylethanol |
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| Ping Xue Xiang Hui Yan Zheng Wang.Lipase immobilized on HOOC-MCF: A highly enantioselective catalyst for transesterification resolution of (R,S)-1-phenylethanol[J].Chinese Chemical Letters,2007,18(8):929-932. |
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| Authors: | Ping Xue Xiang Hui Yan Zheng Wang |
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| Institution: | Key Laboratory of Energy Resources and Chemical Engineering, Ningxia University, Yinchuan 750021, China |
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| Abstract: | Pseudomonas cepacia lipase (PSL) immobilized on the carboxyl-functionalized meso-cellular foams (HOOC-MCF) was used for the transesterification resolution of (R,S)-1-phenylethanol in organic solvent. The results showed that the ee value of (S)-1-phenylethanol and (R)-1-phenylethyl acetate reached 99% with 50% conversion of 1-phenylethanol using toluene as solvent. Furthermore, it was found that PSL/HOOC-MCF exhibited high enantioselectivity in organic solvent with log P ≤ 2 such as toluene and hexane. |
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| Keywords: | Immobilized lipase Enantioselectivity Chiral resolution 1-Phenylethanol |
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