Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications |
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| Authors: | Jingjing Cui Yuhua Yao Cong Chen Rui Huang Weibing Zhang Junhong Qian |
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| Institution: | Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Two fluorescent “off-on” probes YYH1 and YYH2 were used for the detection of mitochondrial polarity and viscosity. Both probes have two emission bands: The peak of shorter wavelength was sensitive to the polarity, while that in longer wavelength region was sensitive to the viscosity, which enables us to detect medium polarity and viscosity simultaneously. The lg(Ishort/Ilong) of YYH1 exhibited linear relationship to the solvent polarity, while that of YYH2 was closely related to the solvent viscosity. Furthermore, both probes showed potential in bioimaging mitochondrial polarity or viscosity in living cells. |
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| Keywords: | Fluorescent probe Mitochondria Microviscosity Micropolarity |
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