| Designing DNA cage-based immuno-fluorescence strategy for rapid diagnosis of clinical cervical cancer tissues |
| |
| 作者姓名： | Juanjuan Li Hongjie Luo Xueqiong Zhu Jianfu Zhao Tianfeng Chen |
| |
| 作者单位： | 1. Department of Oncology, The First Affiliated Hospital, and Department of Chemistry, Jinan University;2. Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University |
| |
| 基金项目： | supported by the National Key R&D Programs of China (No. 2017YFC1103603)；;National Natural Science Foundation of China (No. 21877049)； |
| |
| 摘 要： | Exploiting a tissue diagnosis method to abstain the involuted operating and consume valuable reagents while realizing high-speed and inexpensive pathological grading technology to supply a better scheme for cancer therapy is a significant method of cancers detection. A promising immuno-fluorescence strategy was rationally designed and synthesized by loading ruthenium complex into cervical cancer-targeted DNA-cage, which was well used to realize high-speed and inexpensive diagnosis of clinical ce...
|
| 收稿时间： | 15 April 2021 |
Designing DNA cage-based immuno-fluorescence strategy for rapid diagnosis of clinical cervical cancer tissues |
| |
| Juanjuan Li,Hongjie Luo,Xueqiong Zhu,Jianfu Zhao,Tianfeng Chen.Designing DNA cage-based immuno-fluorescence strategy for rapid diagnosis of clinical cervical cancer tissues[J].Chinese Chemical Letters,2022,33(2):788-792. |
| |
| Institution: | 1. Department of Oncology, The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China;2. Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children''s Hospital of Wenzhou Medical University, Wenzhou 325000, China |
| |
| Abstract: | Exploiting a tissue diagnosis method to abstain the involuted operating and consume valuable reagents while realizing high-speed and inexpensive pathological grading technology to supply a better scheme for cancer therapy is a significant method of cancers detection. A promising immuno-fluorescence strategy was rationally designed and synthesized by loading ruthenium complex into cervical cancer-targeted DNA-cage, which was well used to realize high-speed and inexpensive diagnosis of clinical cervical cancer tumor tissues avoiding the traditional multi-stage process, thus demonstrating high application potential in clinical pathological grading and surgical judgment. Moreover, it has been finding that Apts-DNA@Ru can enrichment in the tumor region, interestingly, no enrichment in normal cervical cancer tissue. It has the potential to realize the integration of in vivo diagnose and further synchronous treatment in the near future. Thence, this study demonstrates a strategy for integration of cancer-targeted DNA-cage and fluorescent RuPOP as alternative IHC reagents for next-generation more rapid convenient cancer detection. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
