| In situ wound sprayable double-network hydrogel: Preparation and characterization |
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| 作者姓名： | Chenglong Cai Ting Wang Xu Han Shaoqiang Yang Chengteng Lai Tao Yuan Zhangqi Feng Nongyue He |
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| 作者单位： | 1. State Key Laboratory of Bioelectronics, National Demonstration Centre for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University;2. Southeast University Jiangbei New Area Innovation Institute;3. Nanjing Jinling Hosp,Dept Orthoped;4. School of Chemical Engineering, Nanjing University of Science and Technology |
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| 基金项目： | supported by the National Natural Science Foundation of China (No. 11204033)；;CMA L’Oreal China Skin Grant 2015 (No.S2015121421)； |
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| 摘 要： | In clinical settings the wound-dressing was required easy to use and can match the wound area immediately, at the same time they need to have the properties of hemostats, anti-inflammation and promoting wound healing. To get an ideal wound dressing, we developed a type of gel-like wound adhesive patch from spraying double-network hydrogel, which own the properties of self-antibacterial and can promote wound healing. By spraying, the gel-like wound adhesive patch can match the wound area immediat...
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| 收稿时间： | 26 July 2021 |
In situ wound sprayable double-network hydrogel: Preparation and characterization |
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| Chenglong Cai,Ting Wang,Xu Han,Shaoqiang Yang,Chengteng Lai,Tao Yuan,Zhangqi Feng,Nongyue He.In situ wound sprayable double-network hydrogel: Preparation and characterization[J].Chinese Chemical Letters,2022,33(4):1963-1969. |
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| Institution: | 1. State Key Laboratory of Bioelectronics, National Demonstration Centre for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China;2. Southeast University Jiangbei New Area Innovation Institute, Nanjing 210096, China;3. Nanjing Jinling Hosp, Dept Orthoped, Nanjing 210002, China;4. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China |
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| Abstract: | In clinical settings the wound-dressing was required easy to use and can match the wound area immediately, at the same time they need to have the properties of hemostats, anti-inflammation and promoting wound healing. To get an ideal wound dressing, we developed a type of gel-like wound adhesive patch from spraying double-network hydrogel, which own the properties of self-antibacterial and can promote wound healing. By spraying, the gel-like wound adhesive patch can match the wound area immediately and form a gel-film in 10 s. Sodium carboxymethyl cellulose as pH sensitive materials accelerated the speed to form the gel-film and enhanced ductility of the wound adhesive patch. In vitro experiments show that, this gel-like wound adhesive patch can promote cell proliferation and reduce cell apoptosis. In vivo studies show that, compared with commercialized wound dressings in clinic using, the spraying gel-like wound adhesive patch from our work has a better effect on wound healing. In conclusion, the spraying gel-like wound patch in our work is easy to use and can form a gel-film match on wound area in a short time, also it has the properties of hemostats, anti-inflammation and promoting wound healing. Its feasibility for mass production shows a good potential for commercial use. |
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