| Facile fabrication of drug-loaded PEGDA microcapsules for drug evaluation using droplet-based microchip |
| |
| 作者姓名： | Xindi Sun Qirui Wu Wei Li Xiuqing Gong Jun-Yi Ge Jinbo Wu Xinghua Gao |
| |
| 作者单位： | Materials Genome Institute, Shanghai University |
| |
| 基金项目： | supported by the National Natural Science Foundation of China (Nos. 31800848 and 21775101)； |
| |
| 摘 要： | Droplet-based microfluidic technology can be utilized as a microreactor to prepare novel functional monodisperse microcapsules. In this study, a droplet-based microfluidic chip with surface modification,which allowed the one-step preparation of double emulsion microcapsules. An O/W/O double emulsion using polyethylene(glycol) diacrylate(PEGDA) solution as the intermediate water phase was prepared by regulating the hydrophilicity and hydrophobicity of the chip surface, with PEGDA microcapsules pr...
|
| 收稿时间： | 25 June 2021 |
Facile fabrication of drug-loaded PEGDA microcapsules for drug evaluation using droplet-based microchip |
| |
| Xindi Sun,Qirui Wu,Wei Li,Xiuqing Gong,Jun-Yi Ge,Jinbo Wu,Xinghua Gao.Facile fabrication of drug-loaded PEGDA microcapsules for drug evaluation using droplet-based microchip[J].Chinese Chemical Letters,2022,33(5):2697-2700. |
| |
| Institution: | Materials Genome Institute, Shanghai University, Shanghai 200444, China |
| |
| Abstract: | Droplet-based microfluidic technology can be utilized as a microreactor to prepare novel functional monodisperse microcapsules. In this study, a droplet-based microfluidic chip with surface modification, which allowed the one-step preparation of double emulsion microcapsules. An O/W/O double emulsion using polyethylene (glycol) diacrylate (PEGDA) solution as the intermediate water phase was prepared by regulating the hydrophilicity and hydrophobicity of the chip surface, with PEGDA microcapsules prepared using UV polymerization. And then anti-tumor drug paclitaxel and neurotoxin 6-OHDA were encapsulated in microcapsules for drug and toxicology evaluation, respectively. Compared to controls, drug-loaded microcapsules caused a significant increase in the death rate of PC12 cells. This indicates that the obtained drug-loaded microcapsules could be used in drug evaluation and potentially in drug screening and delivery. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
