| Two-dimensional coordination polymer-based nanosensor for sensitive and reliable nucleic acids detection in living cells |
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| 作者姓名： | Yuzhi Xu Yanfei Zhang Huihui Yang Wen Yin Leli Zeng Shuo Fang Si-Yang Liu Zong Dai Xiaoyong Zou Yihang Pan |
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| 作者单位： | 1. Precision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University;2. School of Chemistry, Sun Yat-sen University;3. Department of Oncology, The Seventh Affiliated Hospital, Sun Yat-sen University;4. Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University |
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| 基金项目： | supported by the National Key Research and Development Program of China (No. 2018YFA0902801)；;the National Natural Science Foundations of China (Nos. 21775169, 21801259 and 21974153)；;the Scientific Technology Project of Shenzhen City (No. JCYJ20200109142410170)；;the Scientific Technology Project of Guangzhou City (No. 202103000003)；;the Guangdong Natural Science Foundation (Nos. 2018A030313290,2019A1515010587)；;the Guangdong Science and Technology Plan Project (No. 2020B1212060077)；;the Fundamental Research Funds for the Central Universities, SYSU (No. 19lgpy142)； |
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| 摘 要： | A reliable and sensitive strategy which can assess nucleic acid levels in living cells would be essential for fundamental research of biomedical applications. Some nanomaterial-based fluorescence biosensors recently developed for detecting nucleic acids, however, are often with expensive, complicated and timeconsuming preparation process. Here, by using a facile bottom-up synthesis method, a two-dimensional(2 D) coordination polymer(CP) nanosheet, Cu(tz)](Htz = 1,2,4-triazole), was successfully...
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| 收稿时间： | 14 April 2021 |
Two-dimensional coordination polymer-based nanosensor for sensitive and reliable nucleic acids detection in living cells |
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| Yuzhi Xu,Yanfei Zhang,Huihui Yang,Wen Yin,Leli Zeng,Shuo Fang,Si-Yang Liu,Zong Dai,Xiaoyong Zou,Yihang Pan.Two-dimensional coordination polymer-based nanosensor for sensitive and reliable nucleic acids detection in living cells[J].Chinese Chemical Letters,2022,33(2):968-972. |
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| Institution: | 1. Precision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China;2. Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China;3. School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China;4. Department of Oncology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China |
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