| New Facile Synthesis of 2-Aryloxy-5-(2-furfurylidene)- 4H-imidazolin-4-ones |
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| 作者姓名： | Ming Wu DING* Jing ZHU Su Fang SHI Xiao Peng LIU Institute of Organic Synthesis Central China Normal University Wuhan |
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| 作者单位： | Ming Wu DING1*，Jing ZHU2，Su Fang SHI2，Xiao Peng LIU3 1Institute of Organic Synthesis，Central China Normal University，Wuhan 430079 2Department of Chemistry，Central China Normal University，Wuhan 430079 3Center of Analysis and Testing，Central China |
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| 摘 要： | Many N-heterocycles including 4H-imidazolin-4-ones exhibit biological activities1-3. Some derivatives of 5-(2-furfurylidene)-4H-imidazolin-4-one were found to show good antiinflammatory activity4. They can be synthesized by condensation of furfural with 5- unsubsituted 4H-imidazolin-4-ones or from corresponding oxazolones5,6. However, no synthesis of 2-aryloxy substituted 5-(2-furfurylidene)-4H-imidazolin-4-one was reported. Recently, aza-Wittig reaction has received increased attention …
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New Facile Synthesis of 2-Aryloxy-5-(2-furfurylidene)- 4H-imidazolin-4-ones |
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| Ming Wu DING*,Jing ZHU,Su Fang SHI,Xiao Peng LIU Institute of Organic Synthesis,Central China Normal University,Wuhan .New Facile Synthesis of 2-Aryloxy-5-(2-furfurylidene)- 4H-imidazolin-4-ones[J].Chinese Chemical Letters,2002,13(10). |
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| Authors: | Ming Wu DING Jing ZHU Su Fang SHI Xiao Peng LIU |
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| Institution: | Institute of Organic Synthesis, Central China Normal University, Wuhan 430079 Department of Chemistry, Central China Normal University, Wuhan 430079 Department of Chemistry, Central China Normal University, Wuhan 430079 Center of Analysis and Testing, Central China Normal University, Wuhan 430079 |
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| Abstract: | Novel 2-aryloxy-5-(2-furfurylidene)-4H-imidazolin-4-ones 6 were synthesized by aza- Wittig reaction of vinyliminophosphorane 4 with phenyl isocyanate and subsequent condensation with various substituted phenols in the presence of catalytic amount of potassium carbonate. The products are confirmed by 1H NMR, MS, IR and elementary analysis. |
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| Keywords: | 4H-Imidazolin-4-one aza-Wittig reaction iminophosphorane synthesis |
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